Atopic dermatitis
« Gå tillbaka

CYCLOPHILIN D REGULATION OF COLLAGEN SYNTHESIS


Huvudsökande: Ritu bansal
Arbetsplats: Medicine, solna, stockholm


Collagen is the most common type of protein in the body, especially in the skin where the usual types of collagen make up 70% of the weight. Collagen is primarily known as a structural protein with mechanical functions, but a signaling role in the protein is also beginning to be recognized. Too much or too little collagen is an important phenomenon in a variety of diseases and conditions in the skin and other body parts. While the molecular regulation of collagen production is relatively well described in internal organs affected by connective tissue transformation, such as the liver, collagen production is less understood in the skin. We found by chance that increased expression in the skin of cyclophilin D, a protein in the cell's power stations mitochondria, is also associated with an increase in collagen. Furthermore, we found that drug inhibition of cyclophilin D in a pig-based wound healing model was associated with a reduction of the collagen-rich healing flesh, the so-called granulation tissue. Therefore, we suggest that cyclophilin D is involved in the regulation of collagen production. We plan to investigate this with a combined strategy that includes cell culture experiments, advanced study of gene expression and also in a mouse model that lacks cyclophilin D protein. This study has the potential to discover how collagen production is regulated by a completely new link to the mitochondria. This can be important for a number of conditions in the skin and other organs. We plan to investigate this with a combined strategy that includes cell culture experiments, advanced study of gene expression and also in a mouse model that lacks cyclophilin D protein. This study has the potential to discover how collagen production is regulated by a completely new link to the mitochondria. This can be important for a number of conditions in the skin and other organs. We plan to investigate this with a combined strategy that includes cell culture experiments, advanced study of gene expression and also in a mouse model that lacks cyclophilin D protein. This study has the potential to discover how collagen production is regulated by a completely new link to the mitochondria. This can be important for a number of conditions in the skin and other organs.