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The role of microRNAs in the mechanistic links between psoriasis and adipose tissue
Huvudsökande: Ning Xu
Arbetsplats: Molecular Dermatology, Unit of Dermatology and Venerology, Dpt. of Medicine, KI
Psoriasis is a common chronic inflammatory skin disease, which is associated with obesity. MicroRNAs (miRNA) are recently discovered gene expression regulators and we have previously shown that miRNAs in the skin are involved in the pathogenesis of psoriasis. Our proposed study aims to identify the potential role(s) of miRNA in the psoriasis adipose tissue. Specially, the following questions will be addressed: (1) is the miRNAs expression profile different in the subcutaneous (sc) adipose tissue underneath lesional and non-lesional psoriasis skin? (2) Can anti-TNF therapy in psoriasis patients affect the miRNA/mRNA expression profiles in the skin and sc adipose tissue and alter the pathophysiology of co-morbid conditions? (3) How does the gastric bypass surgery for the obese psoriasis patients affect the sc adipose tissue? (4) Is there any difference for the intra-abdominal adipose tissue from psoriasis patients and the obesity matched subjects without psoriasis? (5)What are the functions of the deregulated miRNAs in the adipose tissue of psoriasis patients? The findings of this study will increase our understanding about the psoriasis pathogenesis and the mechanistic links between psoriasis and obesity, which will be beneficial for the effective management of psoriasis and its related co-morbidities.